Ask your healthcare professional how you should dispose of any medicine you do not use.
Sublingual tadalafil is a phosphodiesterase-5 (PDE5) inhibitor. Works by increasing blood flow to the penis during sexual stimulation. The sublingual route offers a discreet and quick method of administration. Patients with kidney or liver issues should consult a physician before use. Avoid grapefruit or grapefruit juice as they may increase tadalafil levels. The drug is not intended for use by women or children. If an erection lasts longer than 4 hours, seek immediate medical help (priapism). Combining with other ED treatments can increase risk of severe side effects.
It is important that you tell all of your doctors that you take tadalafil. If you need emergency medical care for a heart problem, it is important that your doctor knows when you last took tadalafil. If you will be taking this medicine for pulmonary arterial hypertension, it is very important that your doctor check your progress at regular visits.
Sublingual tadalafil may improve onset time compared to standard oral forms. Monitor heart rate and blood pressure when starting the medication. The medication is metabolized in the liver by CYP3A4 enzymes. May cause dizziness; avoid driving or hazardous activities until effects are known. Sublingual dosage strengths vary, typically from 2.5mg to 20mg. Patient adherence can improve due to ease of use and rapid symptom relief. Not suitable for patients with severe hypotension or recent stroke. Report any vision or hearing changes to your healthcare provider immediately.
This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
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Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
What should I do if I accidentally use too much tadalafil?
For oral dosage form (tablets):For treatment of benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) as a single dose, no more than once a day, taken at the same time each day.Children—Use is not recommended.For treatment of erectile dysfunction (as needed):Adults—10 milligrams (mg) as a single dose, no more than once a day, taken 30 minutes before you think sexual activity may occur. Your doctor may adjust your dose as needed.Children—Use is not recommended.For treatment of erectile dysfunction (daily use):Adults—2.5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity. Your doctor may adjust your dose as needed.Children—Use is not recommended.For treatment of erectile dysfunction and benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity.Children—Use is not recommended.For treatment of pulmonary arterial hypertension:Adults—40 milligrams (mg) (two 20 mg tablets) taken once a day. Take both tablets at the same time each day. Your doctor may adjust your dose as needed.Children—Use and dose must be determined by your doctor.
How quickly can I expect sublingual ED medication to work?
For treatment of benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) as a single dose, no more than once a day, taken at the same time each day.Children—Use is not recommended. Adults—5 milligrams (mg) as a single dose, no more than once a day, taken at the same time each day. For treatment of erectile dysfunction (as needed):Adults—10 milligrams (mg) as a single dose, no more than once a day, taken 30 minutes before you think sexual activity may occur. Your doctor may adjust your dose as needed.Children—Use is not recommended. Adults—10 milligrams (mg) as a single dose, no more than once a day, taken 30 minutes before you think sexual activity may occur. Blood and urine tests may be needed to check for unwanted effects.
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If you take tadalafil for pulmonary arterial hypertension, do not take Cialis® or other PDE5 inhibitors, including sildenafil (Revatio® or Viagra®) or vardenafil (Levitra®). If you take too much tadalafil or take it together with these medicines, the chance for side effects will be higher.
What special dietary instructions should I follow?
Your doctor may adjust your dose as needed.Children—Use is not recommended.For treatment of erectile dysfunction and benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at about the same time each day, without regard for the timing of sexual activity.Children—Use is not recommended. For treatment of benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at about the same time each day. Adults—5 milligrams (mg) once a day, taken at about the same time each day. For treatment of erectile dysfunction and benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at about the same time each day, without regard for the timing of sexual activity.Children—Use is not recommended. Adults—5 milligrams (mg) once a day, taken at about the same time each day, without regard for the timing of sexual activity. If you experience a prolonged erection for more than 4 hours or a painful erection for more than 6 hours, contact your doctor immediately.
Mechanism of action
For treatment of benign prostatic hyperplasia (daily use): If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Store the medicine in a closed container at room temperature, away 10 mg tadalafil from heat, moisture, and direct light. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. This condition may require prompt medical treatment to prevent serious and permanent damage to your penis. This medicine does not protect you against sexually transmitted diseases (including HIV or AIDS).
Aspect
Sublingual Tadalafil
Oral Tadalafil
Absorption speed
Faster onset
Slower absorption
Convenience
Immediate release
Longer digestion time
Food interactions
Less affected
More affected by meals
Side effects
Potentially fewer gastrointestinal issues
Similar side effects
Use protective measures and ask your doctor if you have any questions about this.
Condition
Recommended Storage
Additional Notes
Temperature
Below 30°C (86°F)
Keep away from heat or moisture
Light exposure
Keep in a dark place
Protect tablets from light
Humidity
Dry environment
Prevent degradation
Storage location
Out of children’s reach
Safety consideration
It is important to tell your doctor about any heart problems you have now or may have had in the past.
The Advantages of Sublingual Tadalafil
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
J Sex Med
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Abnormal penis, including curved penis and birth defects of the penis (eg, angulation, cavernosal fibrosis, or Peyronie’s disease) or Sickle-cell anemia (blood disorder)—Use with caution. May increase risk of unwanted side effects (eg, prolonged erection of the penis). Crowded optic disc or low cup to disc ratio in the eye (an eye disorder) or Hyperlipidemia (high lipids or fats in the blood) or Non-arteritic anterior ischemic optic neuropathy or NAION (serious eye condition), history of or May increase risk for non–arteritic anterior ischemic optic neuropathy (NAION).
Tadalafil 20 mg Orally On-Demand
Blood vessel problems (eg, aortic stenosis, idiopathic subaortic stenosis) or Heart attack (within the last 3 months) or Heart failure (within the last 6 months) or Retinitis pigmentosa (an inherited eye disorder) or Stroke (within the last 6 months)—Should not be used in patients with these conditions. Stomach ulcers—Use must be determined by your doctor. Pulmonary veno-occlusive disease or PVOD (a type of lung disease)—Use with caution. Liver disease, mild or moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body. This medicine can cause serious side effects in patients with heart problems.
Side Effect
Frequency
Severity
Headache
Common
Mild to moderate
Flushing
Common
Mild
Dizziness
Less common
Mild
Nasal congestion
Less common
Mild
Indigestion
Less common
Mild
Do not use this medicine if you are also using riociguat (Adempas®) or a nitrate medicine, often used to treat angina (chest pain).
Further information
Your doctor may adjust your dose as needed. For treatment of erectile dysfunction (daily use):Adults—2.5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity. Adults—2.5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity. For treatment of erectile dysfunction and benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity.Children—Use is not recommended. Adults—5 milligrams (mg) once a day, taken at the same time each day, without regard for the timing of sexual activity.
US Brand Name
For treatment of pulmonary arterial hypertension:Adults—40 milligrams (mg) (two 20 mg tablets) taken once a day. Adults—40 milligrams (mg) (two 20 mg tablets) taken once a day. Children—Use and dose must be determined by your doctor. For treatment of benign prostatic hyperplasia (daily use): For oral dosage form (chewable tablet):For treatment of benign prostatic hyperplasia (daily use):Adults—5 milligrams (mg) once a day, taken at about the same time each day. Your doctor may adjust your dose as needed.Children—Use is not recommended.For treatment of erectile dysfunction (as needed):Adults—10 milligrams (mg) as a single dose, no more than once a day, taken 30 minutes before you think sexual activity may occur. Some illegal ("street") drugs called "poppers" (such as amyl nitrate, butyl nitrate, or nitrite) also contain nitrates.
What is Tadalafil?
Use tadalafil exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking first with your doctor. This medicine comes with a patient information leaflet. Read it again each time you refill your prescription in case there is new information.
What should I know about tadalafil before using it?
Ask your doctor if you have any questions. You may take this medicine with or without food. Do not split, break, chew, or crush it. Chewable tablets: Chew the tablet completely before swallowing. When using this medicine for erectile dysfunction, the ability to have sexual activity may be improved for up to 36 hours after taking the tablet.
The Science Behind Sublingual Absorption
Use only the brand tadalafil daily of this medicine that your doctor prescribed. Different brands may not work the same way. Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may change the amount of this medicine that is absorbed in the body. The dose of this medicine will be different for different patients.
